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3,4-Methylenedioxymethamphetamine, commonly known as ecstasy, is a psychoactive drug used primarily as a recreational drug. Desired effects include increased empathy, euphoria, and heightened sensations.
Biological half-life: (R)-MDMA: 5.8 ± 2.2 hours; (S)-MDMA: 3.6 ± 0.9 hours
Onset of action: 30-45 minutes (by mouth)
Duration of action: 4-6 hours
Metabolism: Liver, CYP450 extensively involved, including CYP2D6
Metabolites: MDA, HMMA, HMA, DHA, MDP2P, MDOH
Addiction liability: Low-moderate.
How do people use MDMA?
People who use MDMA usually take it as a capsule or tablet, though some swallow it in liquid form or
snort the powder. The popular nickname Molly (slang for “molecular”) often refers to the supposedly
“pure” crystalline powder form of MDMA, usually sold in capsules. However, people who purchase
powder or capsules sold as Molly often actually get other drugs such as synthetic cathinones (“bath
How does MDMA affect the brain?
MDMA increases the activity of three brain chemicals:
Dopamine-causes a surge in euphoria and increased energy/activity
Norepinephrine-increases heart rate and blood pressure, which are particularly risky for people with heart and blood vessel problems Serotonin-affects mood, appetite, sleep, and other functions. It also triggers hormones that affect sexual arousal and trust. The release of large amounts of serotonin likely causes the emotional closeness, elevated mood, and empathy felt by those who use.Ecstasy is the street term for a range of drugs similar in structure to MDMA (methylenedioxymethamphetamine). Ecstasy is similar in structure and effect to amphetamines and other hallucinogens.These substances are stimulants that speed up activity in the nervous system. Because of their hallucinogenic properties, they typically affect perception and can cause things to appear distorted, or things that don’t exist to be seen or heard
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